What is this test?
Total PSA measures a protein produced by the prostate. It may be involved in an individual screening decision and in the evaluation or follow-up of prostate disease.
Why might it be ordered?
- As part of an informed screening decision based on age, risk and patient preference.
- For urinary or prostate symptoms, or for follow-up after an established diagnosis and treatment.
What sample is needed?
A healthcare professional collects a venous blood sample. Depending on the method, the laboratory uses serum or plasma.
How should you prepare?
Report any urinary infection, urinary retention, recent prostate procedure and prostate medicines. Follow the laboratory guidance about waiting after ejaculation, cycling or prostate manipulation. Tell the laboratory about all medicines, hormone treatments, vitamins and supplements you take. Do not stop or change treatment unless your clinician tells you to. Follow any instructions about fasting and the time of collection.
How should you understand the result?
PSA may rise with a benign enlargement, inflammation, infection, or recent manipulation. The significance depends on age, trend, examination and individual risk. A trend across consecutive measurements made with a comparable method is often more informative than a single value.
Sources and editorial status
This patient-facing text is an editorial draft. It should be approved by a laboratory physician before official publication.