What is this test?
SHBG is a protein that transports testosterone and estradiol in the blood and affects how much of it is free and available to the tissues.
Why might it be ordered?
- When symptoms do not match total testosterone or estradiol.
- For a more accurate assessment of androgen balance in menstrual disorders, hair loss, infertility or sexual symptoms.
What sample is needed?
A healthcare professional collects a venous blood sample. Depending on the method, the laboratory uses serum or plasma.
How should you prepare?
Tell the laboratory about all medicines, hormone treatments, vitamins and supplements you take. Do not stop or change treatment unless your clinician tells you to. Follow any instructions about fasting and the time of collection.
How should you understand the result?
SHBG is interpreted with total testosterone, albumin and, when needed, calculated free testosterone. Liver and thyroid function, body weight and hormone medicines can affect it. Your result is interpreted using the reference interval on the laboratory report and in the context of your symptoms, medical history and other test findings.
Sources and editorial status
This patient-facing text is an editorial draft. It should be approved by a laboratory physician before official publication.