What is this test?
Anti-ssDNA IgG are antibodies against single-stranded DNA. They can be found in various autoimmune and inflammatory conditions, but are less specific than anti-dsDNA.
Why might it be ordered?
- As an adjunctive investigation in the specialized evaluation of systemic autoimmune disease.
- Along with an ANA profile and other more specific antibodies when the rheumatologist decides.
What sample is needed?
A healthcare professional collects a venous blood sample. Depending on the method, the laboratory uses serum or plasma.
How should you prepare?
Tell the laboratory about all medicines, hormone treatments, vitamins and supplements you take. Do not stop or change treatment unless your clinician tells you to. Follow any instructions about fasting and the time of collection.
How should you understand the result?
The quantitative value reports the anti-ssDNA IgG level measured by that method. A positive result has limited meaning without compatible symptoms and other antibody findings. A positive result means the tested antibodies were detected, but it does not establish a diagnosis on its own. A negative result does not rule out every autoimmune condition.
Sources and editorial status
This patient-facing text is an editorial draft. It should be approved by a laboratory physician before official publication.