What is this test?
AMAs are antibodies against structures in the mitochondria of cells. They are most often used to aid in the evaluation of primary biliary cholangitis.
Why might it be ordered?
- In persistently abnormal liver parameters, especially alkaline phosphatase.
- With symptoms or imaging data that point to an autoimmune disease of the small bile ducts.
What sample is needed?
A healthcare professional collects a venous blood sample. Depending on the method, the laboratory uses serum or plasma.
How should you prepare?
Tell the laboratory about all medicines, hormone treatments, vitamins and supplements you take. Do not stop or change treatment unless your clinician tells you to. Follow any instructions about fasting and the time of collection.
How should you understand the result?
A positive result is interpreted with liver enzymes, symptoms and imaging; more specific antibody tests may sometimes be needed. A positive result means the tested antibodies were detected, but it does not establish a diagnosis on its own. A negative result does not rule out every autoimmune condition.
Sources and editorial status
This patient-facing text is an editorial draft. It should be approved by a laboratory physician before official publication.